Never Miss a New Discovery.
From a young age, I knew I am going to be a scientist, and it’s a decision I have never regretted. For me, there is nothing better than the challenge and excitement that each new research brings.
As an enthusiastic and devoted Scientist and educator, I see no better purpose in life than passing on my love of exploring to my own students.
PUBLICATION PICK OF THE MONTH
Targeting neurons in the tumor microenvironment with bupivacaine nanoparticles reduces breast cancer progression and metastases
Maya Kaduri et al.
"We demonstrate that signaling between triple-negative breast cancer cells (4T1) and neurons involves secretion of cytokines stimulating neurite outgrowth. Reciprocally, neurons stimulated 4T1 proliferation, migration, and survival through secretion of neurotransmitters. Bupivacaine curbs neurite growth and signaling with cancer cells, inhibiting cancer cell viability. In vivo, bupivacaine-loaded nanoparticles intravenously administered suppressed neurons in orthotopic triple-negative breast cancer tumors, inhibiting tumor growth and metastatic dissemination. Overall, our findings suggest that reducing nerve involvement in tumors is important for treating cancer."