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Artificially Intelligent Nanoarray Detects Various Cancers by Liquid Biopsy of Volatile Markers

Nanoarray Detects Various Cancers


Here, a new approach for liquid biopsies is proposed, based on volatile organic compound (VOC) patterns in the blood headspace. An artificial intelligence nanoarray based on a varied set of chemi-sensitive nano-based structured films is developed and used to detect and stage cancer. As a proof-of-concept, three cancer models are tested showing high incidence and mortality rates in the population: breast cancer, ovarian cancer, and pancreatic cancer. The nanoarray has >84% accuracy, >81% sensitivity, and >80% specificity for early detection and >97% accuracy, 100% sensitivity, and >88% specificity for metastasis detection.


“We have shown that cancer-specific VOCs in mice models' blood samples can be accurately detected by our artificially intelligent array of cross-reactive nanomaterial-based chemical sensors.”

Keywords

Nanoarray, Cancer, Volatile markers


The ability to detect cancer-related VOCs patterns using our artificially intelligent nanoarray in small concentrations in a complex medium as blood by changing only mathematical models is promising and promotes developing of highly accurate early detection and monitoring tool for cancer. This non-invasive monitoring method will grant physicians the ability to determine the exact stage of tumor development, allowing them to “tailor” the specific treatment that will lead to the optimal therapeutic results at that particular time.


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