Traumatic brain injury (TBI) can have long-lasting physical, emotional, and cognitive consequences due to the neurodegeneration caused by its robust inflammatory response.
Despite advances in rehabilitation care, effective neuroprotective treatments for TBI patients are lacking.
"This research introduces a novel approach for delivering dexamethasone enclosed within liposomal nanoparticles to the brain following a brain injury in mice. The findings illustrate a significant decrease in both brain damage and the associated inflammatory response, all without inducing any toxic effects. This innovative brain-targeted delivery method holds promising potential for enhancing the efficacy of trauma treatments."
Keywords
Traumatic Brain Injury, Biomimicry, Nanoparticles, Drug Delivery, Central Nervous System
Our findings demonstrate that Lipo-Dex can selectively target the injured brain, thereby reducing lesion volume, cell death, astrogliosis, the release of pro-inflammatory cytokines, and microglial activation compared to Lipo-treated mice in a sex-dependent manner, showing a major impact only in male mice. This highlights the importance of considering sex as a crucial variable in developing and evaluating new nano-therapies for brain injury. These results suggest that Lipo-Dex administration may effectively treat acute TBI.
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