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Engineering Biomimetic Nanoparticle Performance Through Fabrication Method Selection: Turbulent Jet Mixing, Microfluidics, and Extrusion
These results highlight the critical influence of fabrication techniques on BNP structure and function and provide actionable insights for optimizing production strategies, facilitating the scalable development of targeted nanotherapeutics.


Selective Membrane Protein Enrichment Enables Defined Biomimetic Nanoparticles for Endothelial Targeting
This protein-defined biomimetic nanoparticle platform offers enhanced targeting efficiency, improved reproducibility, and translational potential for inflammation-targeted therapies.


Designing nanomedicine to overcome therapeutic challenges in pregnancy
Illness during pregnancy presents a therapeutic dilemma: treatment must protect the mother without compromising fetal health. Yet, most drugs remain insufficiently studied in pregnancy. Understanding pregnancy stage-specific drug pharmacokinetics and placental drug transport can guide the design of nanomedicine to optimize treatments during pregnancy.


Synergistic kappa-carrageenan/konjac-glucomannan hydrogels for the tunable and controlled release of biomimetic nanoparticles
Our novel hydrogel platform offers a promising approach for the tunable controlled release of BNPs, with potential applications for inflammation and other therapeutic models.


Harnessing the Potential of Human Breast Milk to Boost Intestinal Permeability for Nanoparticles and Macromolecules
Herein, we propose a comprehensive investigation into two distinct milk types and a milk synthetic formula as potential enhancers of intestinal permeation, aiming to facilitate the oral delivery of liposomes and macromolecules.


Harnessing RNA technology to advance therapeutic vaccine antigens against chagas disease
Our results show several therapeutic benefits, including reductions in parasite burdens and cardiac inflammation, with each mRNA antigen, es


Sex-dependent improvement in traumatic brain injury outcomes after liposomal delivery of dexamethasone in mice
This research introduces a novel approach for delivering dexamethasone enclosed within liposomal nanoparticles to the brain following a TBI


Nanovesicles for Neuron Targeting
Enhancing neuron targeting using humanized biomimetic nanovesicles. Our results establish that both endogenous and genetically engineered...


Traumatic Brain Injury
Biomimetic Nanoparticles as a Theranostic Tool for Traumatic Brain Injury. Traumatic brain injury (TBI) triggers both central and...


Inflammation Targeting
Enhancing inflammation targeting using tunable leukocyte-based biomimetic nanoparticles. Here we show that, while increasing the...


Treating Cardiovascular Diseases
Biomimetic nano drug delivery carriers for treating cardiovascular diseases NPs hold great promise for detecting and treating CVD. Among...


Bioinspired Extracellular Vesicles
Lessons Learned From Nature for Biomedicine and Bioengineering Efficient communication is essential in all layers of the biological...


Ponatinib Encapsulation into Biomimetic Lipid Nanoparticle
Reproducible and Characterized Method for Ponatinib Encapsulation into Biomimetic Lipid Nanoparticles as a Platform for Multi-Tyrosine...


Leukocyte-mimicking nanovesicles
fLeukocyte-mimicking nanovesicles for effective doxorubicin delivery to treat breast cancer and melanoma. Here we report the use of...


Biomimetic nanoparticles reverse vascular inflammation
Rapamycin-Loaded Biomimetic Nanoparticles Reverse Vascular Inflammation. Here, we have used biomimetic nanoparticles to deliver rapamycin...


Macrophage-derived nanovesicles
Macrophage-derived nanovesicles exert intrinsic anti-inflammatory properties and prolong survival in sepsis through a direct interaction...


miRNA trafficking
Melanoma miRNA trafficking controls tumour primary niche formation. Here, we show that melanoma cells directly affect the formation of...
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