Designing nanomedicine to overcome therapeutic challenges in pregnancy

Illness during pregnancy presents a therapeutic dilemma: treatment must protect the mother without compromising fetal health. Yet, most drugs remain insufficiently studied in pregnancy. Understanding pregnancy stage-specific drug pharmacokinetics and placental drug transport can guide the design of nanomedicine to optimize treatments during pregnancy.

"Pregnancy should not be regarded as a peripheral consideration in therapeutic development but instead recognized as a defining frontier in nanomedicine innovation."

Keywords

Pregnancy, Women health, nanomedicine, nanoparticles,

By considering maternal–fetal physiologyand placental biology, nanomedicines can be engineered and optimized for treatments during pregnancy, leveraging biomimetic

and adaptive design strategies to ensure maternal efficacy, placental

selectivity and fetal safety.

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