Selective Membrane Protein Enrichment Enables Defined Biomimetic Nanoparticles for Endothelial Targeting

This protein-defined biomimetic nanoparticle platform offers enhanced targeting efficiency, improved reproducibility, and translational potential for inflammation-targeted therapies.

"Together, these results highlight the potential of PNPs as a new class of protein-defined biomimetic nanocarriers capable of mimicking leukocyte-like vascular interactions with high precision and reproducibility."

Keywords

bioengineering, biomimetic nanoparticles, drug delivery, inflammation, membrane proteins , translational research

Beyond inflammation-targeted delivery, this platform can be readily adapted to incorporate alternative protein repertoires for tissue- or disease-specific applications, paving the way for more rationally designed and clinically translatable biomimetic nanomedicines.

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