Engineering Biomimetic Nanoparticle Performance Through Fabrication Method Selection: Turbulent Jet Mixing, Microfluidics, and Extrusion

These results highlight the critical influence of fabrication techniques on BNP structure and function and provide actionable insights for optimizing production strategies, facilitating the scalable development of targeted nanotherapeutics.

"Notably, this study presents the first application of high-resolution LC-MS/MS proteomics to quantitatively compare membrane-associated protein profiles across fabrication methods."

Keywords

bioengineering, biomimetic nanoparticles, drug delivery, inflammation, membrane proteins , translational research

This study provides a head-to-head comparison of BNP fabrication strategies, linking processing conditions to physicochemical stability, drug loading and release, protein incorporation, and functional performance. These insights offer mechanistic understanding and practical guidance for the rational design, scalable production, and translational development of next-generation biomimetic nanocarriers.

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