Macrophage-derived nanovesicles exert intrinsic anti-inflammatory properties and prolong survival in sepsis through a direct interaction with macrophages.
Here, we investigated the role of macrophage-derived biomimetic nanoparticles, namely leukosomes, in a lipopolysaccharide-induced murine model of sepsis. We observed that treatment with leukosomes was associated with significantly prolonged survival. In vitro studies elucidated the potential mechanism of action of these biomimetic vesicles.
“Despite numerous advances in medical treatment, sepsis remains one of the leading causes of death worldwide. Sepsis is characterized by the involvement of all organs and tissues as a consequence of blood poisoning, resulting in organ failure and eventually death."
In this paper, we showed that leukosomes are endowed with
intrinsic anti-inflammatory features and provided a significant
survival advantage in a mouse model of systemic inflammation. Previous work with biomimetic nanoparticles derived from J774 macrophages for septic treatment relied only on their ‘nanosponge effect’, i.e. ability to remove LPS and proinflammatory cytokines from the blood.