Harnessing the Potential of Human Breast Milk to Boost Intestinal Permeability for Nanoparticles and Macromolecules

Herein, we propose a comprehensive investigation into two distinct milk types and a milk synthetic formula as potential enhancers of intestinal permeation, aiming to facilitate the oral delivery of liposomes and macromolecules.

"Our results underscore the unexploited potential of human breast milk in facilitating transport across the intestinal barrier, offering novel avenues for human nutritional delivery and therapeutic interventions."

Keywords

Nanoparticles, Liposomes, Human breast milk, Oral delivery, Intestinal permeability, Human breast milk protein corona

Our findings propose a novel strategy for oral drug delivery and the absorption of therapeutic agents, likely due to the interaction of human breast milk proteins with liposome surfaces and their engagement with the mucus and epithelial layers of the intestine. The enhanced absorption and bioavailability facilitated by human breast milk could have significant implications for improving patient quality of life, particularly for those managing chronic and acute diseases

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