Biomimetic Nanoparticles as a Theranostic Tool for Traumatic Brain Injury.
Traumatic brain injury (TBI) triggers both central and peripheral inflammatory responses. Existing pharmacological drugs are unable to effectively and quickly target the brain inflamed regions, setting up a major roadblock towards effective brain trauma treatments.
“Our results suggest that NPs represent a promising future theranostic tool for TBI treatment.”
In this work, we have demonstrated the feasibility of using biomimetic NPs as a theranostic tool for TBI treatment. We have developed a novel delivery system that 1) penetrates the injured brain while carrying a fluorescent agent that targets the local brain inflammation; 2) can be used as a diagnostic tool for BBB breaching; and 3) reduces the lesion size.