Nanoparticles target early-stage breast cancer metastasis in vivo.
In this study we demonstrate that 100 nm liposomes target triple-negative murine breast-cancer metastases post intravenous administration. Metastatic breast cancer was induced in BALB/c mice either experimentally, by a tail vein injection of 4T1 cells, or spontaneously, after implanting a primary tumor xenograft.
“Despite advances in cancer therapy, treating cancer after it has metastasized remains an unmet clinical challenge.”
In summary, this study demonstrates that 100 nm liposomes target triple negative murine breast cancer metastasis. Our findings support the use of nanotechnology for imaging and targeting medicines to metastases and ultimately to the pre-metastatic niche.