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Proteolytic Nanoparticles

Proteolytic Nanoparticles Replace a Surgical Blade by Controllably Remodeling the Oral Connective Tissue.

Surgical blades are common medical tools. However, blades cannot distinguish between healthy and diseased tissue, thereby creating unnecessary damage, lengthening recovery, and increasing pain.

“We propose that surgical procedures can rely on natural tissue remodeling tools—enzymes, which are the same tools our body uses to repair itself.”


this study provides an approach for degrading connective tissue using proteolytic enzymes housed in nanoparticles rather than by surgical intervention. Combining

nanotechnology and enzymatic drug delivery may prove effective in treating conditions where a tissue must be remodeled in a specific manner. This noninvasive procedure was shown to shorten the treatment time and improve



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